IMG Banner

Imaging remains an important tool in oncology drug discovery and development. This noninvasive technology delivers significant time and cost reduction when used systematically and skillfully. Cambridge Healthtech Institute’s Imaging in Cancer Drug Development is designed to bring together leading imaging experts from industry and academia, as well as scientists and clinicians who use their services to accelerate cancer research.

Final Agenda


Day 1 | Day 2 | Speaker Biographies | Download Brochure 

Wednesday, June 10

7:00 am Registration and Morning Coffee


TRANSLATIONAL IMAGING IN ONCOLOGY

7:55 Chairperson’s Opening Remarks

Paul McCracken, Ph.D., Director of Imaging, Biomarkers and Personalized Medicine CFU, Eisai 

 

8:00 KEYNOTE PRESENTATION: ENGINEERING THE CANCER GENOME

Tyler-JacksTyler Jacks, Ph.D., Koch Institute for Integrative Cancer Research at MIT




 

8:30 Session Break

8:35 Improving Decision Making For Drug Discovery and Early Development In Oncology With Imaging

PaulMcCrackenPaul McCracken, Ph.D., Director of Imaging, Biomarkers and Personalized Medicine CFU, Eisai

Due to high cost and low probability of success, the pharmaceutical industry needs to improve the decision making process for compounds entering Phase I, better using Phase I studies for decision making beyond safety, and improving the quality of compounds entering clinical trials. Imaging biomarkers can significantly contribute to the decision making process, such as supporting target engagement, proof of concept, drug safety, patient selection, and dose selection.

9:05 Enabling Translational Cancer Research and Drug Development Through The Integration Of Preclinical Imaging

QuangDeNguyenQuang-Dé Nguyen, Ph.D., Director of the Lurie Family Imaging Center, Senior Scientist, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute

The Lurie Family Imaging Center (LFIC), the preclinical arm of the Center for Biomedical Imaging in Oncology (CBIO) at the Dana-Farber Cancer Institute, is a state-of-the-art imaging facility that conducts interdisciplinary in vivo translational and experimental therapeutics studies focused on cancer, with an emphasis on assessment of novel cancer therapeutics, multimodality imaging of cancer, molecular imaging of pharmacodynamic efficacy, development of novel probes and target validation. 

 

 

9:35 Click-mediated Therapy for HER2-positive Breast Cancer 

DmitriArtemovDmitri Artemov, Ph.D., Associate Professor, Radiology and Oncology, The Johns Hopkins University School of Medicine

Treatment of HER2-positive tumors that have innate or acquired resistant to trastuzumab is an important clinical problem. Here we report a two-component delivery system for induced internalization of HER2-targeted nanocarriers with therapeutic cargo based on click-chemistry in situ reaction between the pretargeting and therapy carreir components. This pretargeting strategy provides image guidance for therapeuetic applications and has been validated in preclinical models of breast cancer.

10:05 Coffee Break in the Exhibit Hall with Poster Viewing


TRANSLATIONAL IMAGING IN ONCOLOGY (CONTINUED)

10:50 Use of Echocardiography for Safety De-Risking of Oncology Drug Candidates

TerriSwansonTerri A. Swanson, MA, LATg, PMP, Preclinical Ultrasound, Global Science & Technology Worldwide Comparative Medicine, Pfizer

Cardiotoxicity is a common finding in safety studies of oncology drug candidates. Changes in cardiac function are an important endpoint for patients taking these medications. We will discuss the use of high frequency ultrasound echocardiography in the rodent for predicting cardiac safety from oncology candidates and certain classes of compounds. Rodent and large animal echocardiography provides standard clinical endpoints such as ejection fraction, fractional shortening and cardiac output for these studies and can be directly translated to the human clinic.

11:20 Proteomic Imaging of Caveolae to Penetrate Solid Tumors

JanSchnitzerJan E. Schnitzer, M.D., Director, Professor of Cellular & Molecular Biology, PRISM, Proteogenomics Research Institute for Systems Medicine

Access inside solid tumors is poor yet critical for imaging and therapeutic agents to be effective. These agents rely on passive movement across endothelial barriers to reach targets inside tumors. Our “proteomic-imaging” efforts discovered a new pathway and class of delivery targets for active transport into tumors. In vivo imaging reveals caveolae-targeted antibodies, drugs, imaging agents, and nanoparticles being pumped across endothelium to achieve >100-fold more tumor delivery and efficacy.

11:50 Sponsored Presentation (Opportunity Available)

12:20 pm Luncheon Presentation (Sponsorship Opportunity Available) or Enjoy Lunch on Your Own

1:00 Refreshment Break in the Exhibit Hall with Poster Viewing


IMAGING ADVANCES AND END POINTS IN CANCER RESEARCH

1:30 Chairperson’s Remarks

Susanta Sarkar, Ph.D., Director, Translational/Clinical Imaging, Sanofi Oncology

1:35 Translational Imaging in Oncology

DanielBradleyDaniel P. Bradley, Ph.D., Head of Biomedical Imaging at Takeda Boston, Takeda Pharmaceuticals International Co.

Daniel will present on a number of programs that he has directly worked on, or working on, that have been developed in translational imaging in oncology. Importantly, this talk will highlight important lessons learned about collaboration, timing, perspectives and science with a hope that other groups in the imaging community can leverage this information for future developments. The Biomedical Imaging Group balances its portfolio between the use of conventional imaging biomarkers used in a novel biological and/or pharmacological context to advanced imaging techniques.

2:05 Non-Invasive and Simultaneous Measurement of Pharmacokinetics and Pharmacodynamics in Preclinical Cancer Models

WernerScheuerWerner Scheuer, Research Leader, Pharma Research and Early Development, Discovery Oncology, Roche Diagnostics GmbH

Non-invasive imaging modalities (optical and micro-computed tomography) in combination with ex vivo analysis (3D-multispectral fluorescence microscopy, FACS) are an undispensable tool to assess the anti-tumoral efficacy of new compounds. Proliferation of tumor cells, metastasis, angiogenesis, and induction of apoptosis as well as phosphorylation of kinases can be monitored in mice carrying tumor cells s.c. or orthotopically. The quantification of these pharmacodynamics (Pd) read-outs are combined with optical pharmacokinetics (Pk). The simultaneous measurement of Pd and Pk reduces the number of animals significantly and provides a comprehensive evaluation of new drugs.

2:35 Normalizing Tumor Microvasculature and Microenvironment

DaiFukumuraDai Fukumura, M.D., Ph.D., Deputy Director, Edwin L. Steele Laboratory; Biologist, Department of Radiation Oncology, Massachusetts General Hospital; Associate Professor, Harvard Medical School

Intravital microscopy techniques and sophisticated animal models have been providing unprecedented molecular, cellular, anatomical and functional insights in tumor biology. Tumor microvasculature is structurally and functionally abnormal hindering drug delivery and inducing a hostile microenvironment that causes ineffectiveness of anti-tumor treatments. Imbalance of pro- and anti-angiogenic factors is causing these pathophysiological features in the tumor. Hence, restoring the balance of these factors in tumors may “normalize” tumor vasculature, improve its function and microenvironment, and enhance the efficacy of cytotoxic therapies.

3:05 Companion Diagnostic Co-Development Models

Susanta Sarkar, Ph.D., Director, Translational/Clinical Imaging, Sanofi Oncology

A number of antibody-drug conjugates (ADC) are currently in clinical trials driven by recent technological progress. However, most ADC targets are not universally expressed on a given tumor type and will require a companion diagnostic to select patients that are likely to benefit from the particular ADC. A non-invasive imaging-based companion diagnostic will allow real time measurement of antigen expression in the tumor, thus enabling patient stratification in real time by identifying patients who are likely to respond to the ADC.

3:35 Sponsored Presentation (Opportunity Available)

4:05 Refreshment Break in the Exhibit Hall with Poster Viewing


5:00 PLENARY KEYNOTE PANEL - click here for detailed agenda 

6:00 Welcome Reception in the Exhibit Hall with Poster Viewing

7:00 Close of Day


Day 1 | Day 2 | Speaker Biographies | Download Brochure 

Thursday, June 11


7:30 am Interactive Breakout Discussion Groups

Each discussion group in this session is led by a moderator/s who ensures focused conversations around key issues. Attendees join a specific group and the small, informal setting facilitates sharing of ideas and active networking. Topics for discussion will be made available on the conference website.



CASE STUDIES

8:35 Preclinical Development of Peptide Radiotracers for Detecting Visceral Amyloid Associated with Multiple Myeloma

JonathanWallJonathan Wall, Ph.D., Professor of Medicine, Human Immunology and Cancer Program; Director, Amyloid and Preclinical Molecular Imaging Laboratory, University of Tennessee Graduate School of Medicine

Multiple myeloma, the second most common hematologic malignancy in the US, and related plasma cell dyscrasias, are characterized by the secretion of monoclonal immunoglobulin light chains that often deposit as insoluble amyloid fibrils in visceral organs. The abundance of amyloid deposits and their anatomic distribution often inform prognosis and treatment options. At present there are no clinical methods for the non-invasive, quantitative measurement of amyloid. To this end we have generated synthetic, poly-basic peptides that preferentially bind amyloid and, when radiolabeled, can be used for disease detection by molecular imaging.

9:05 PARP1 Status Annotation in Cancers of the Oral Cavity

ThomasReinerThomas Reiner, Ph.D., Assistant Member, Memorial Sloan-Kettering Cancer Center; Assistant Attending Chemist, Radiochemistry & Imaging Sciences Service; Assistant Professor, Weill Cornell Medical College

The enzyme PARP1 has attracted attention for its diagnostic and prognostic value, and quantification of PARP1 expression could impact the clinical decision-making process directly. A noninvasive imaging tool that can unambiguously quantify the expression of PARP1 in vivo, however, is an unmet clinical goal. Here, we report on the use of a PARP1 imaging agent as a probe for the early detection of oral cancer, discuss its pharmacological properties and selectivity in vivo, and illustrate its potential impact on future clinical research.

9:45 Utility of 3D Ultrasound and Photoacoustic Imaging in Subject Stratification and Treatment Prediction

SrivalleeshaMallidiSrivalleesha Mallidi, Ph.D., Research Fellow, Laboratory of Tayyaba Hasan, Harvard-MIT

Prediction of response and tumor recurrence following a given therapy is necessary for effective treatment. In this talk, we demonstrate an approach towards this goal with an example of photodynamic therapy (PDT) as the treatment modality and photoacoustic imaging (PAI) as a non-invasive, response and disease recurrence monitor in a murine model of glioblastoma (GBM). PDT is a photochemistry-based, clinically used technique that consumes oxygen to generate cytotoxic species thus causing changes in blood oxygen saturation (StO2).

10:15 Sponsored Presentation (Opportunity Available)

10:45 Coffee Break in the Exhibit Hall with Poster Viewing


Image guided interventions

11:30 Mass Spectrometry for Image-Guided Therapy

 NathalieAgarNathalie Y.R. Agar, Ph.D., Assistant Professor of Neurosurgery, Assistant Professor of Radiology, Harvard Medical School, Director, Surgical Molecular Imaging Laboratory, Department of Neurosurgery, Brigham and Women's Hospital  





12:00 PM KEYNOTE PRESENTATION: CLINICAL TRANSLATION OF NEAR-INFRARED FLUORESCENCE IMAGING FOR IMAGE-GUIDED SURGERY

JohnFrangioniJohn V. Frangioni, M.D., Ph.D., Professor, Department of Medicine and Radiology, Harvard Medical School

Invisible near-infrared (NIR) light in the 700 nm to 900 nm range penetrates several millimeters into living tissue. In conjunction with target-specific fluorescent contrast agents, NIR light can highlight all desired structures on the surgical field, such as tumors that need to be resected and critical structures that need to be avoided. This talk will introduce the first principles of near-infrared light for surgical guidance and review clinical translation of NIR imaging systems and contrast agents.


12:30 Close of Conference



Day 1 | Day 2 | Speaker Biographies | Download Brochure 



Suggested Event Package:

June 9 Dinner Short Course*: Imaging in Cancer Research 

June 10-11: Translational Imaging in Cancer Drug Development Conference 

June 11-12: Tumor Models for Cancer Immunotherapy Conference 


* Separate registration required.

 

WPC 

Register Now 


Arrow Event At A Glance 


Arrow Final Brochure 


Arrow View All Sponsors 


Arrow View All Media Partners 


Arrow Student Fellowships 



PREMIER SPONSOR

Jackson Laboratory
 


SPONSORSHIPS & EXHIBITS

The exhibit hall has sold out the past four years, so please contact us early to reserve your place. To customize your sponsorship or exhibit package for 2015, contact:

Joseph Vacca
Associate Director, Business Development
781-972-5431
jvacca@healthtech.com 

 

 

Testimonials

WPC Quotes