Mechanistic Insights into Hepatotoxicity
June 16, 2010
The course is designed for both pre-clinical and clinical scientists looking to better understand the mechanisms underlying drug-induced liver injury or DILI, and to help in the development of technologies and mechanism-based assays for early prediction of drug-induced hepatotoxicity. Click here for more information
Dealing with the Blood-Brain Barrier
June 14, 2010
Achieving blood-brain barrier (BBB) penetration remains a significant hurdle for successfully prosecuting CNS targets. Click here for more information
Animal Models of Pain
Many are frustrated with the lack of translational progress in the pain field, in which huge gains in basic science knowledge obtained using animal models have not led to the development of many novel, clinically effective compounds. A careful reexamination of animal models of pain is therefore warranted. In this course, I will describe the current implementation of animal models of pain, discuss a wide range of modulatory factors affecting data obtained within them, lay out the case for the replacement of current models by more sophisticated ones, and describe progress toward that goal.